ea0026oc5.1 | Hormone metabolism and action | ECE2011
Hoekstra M
, Vergeer M
, Hildebrand R B
, van der Sluis R J
, Kastelein J J
, Van Eck M
, Kuivenhoven J A
, Van Berkel T J C
Adrenal-derived glucocorticoids originate from their precursor cholesterol. Scavenger receptor BI (SR-BI) is a major high-density lipoprotein (HDL) receptor that mediates the selective uptake of cholesteryl esters (CE) from this lipoprotein in the circulation. In our present studies in SR-BI knockout (KO) mice and human carriers of a functional mutation in the extracellular domain of SR-BI (P297S), we determined whether SR-BI-mediated uptake of HDL-CE is required for adrenal g...